3D cell culture systems: tumor application, advantages, and disadvantages

O Habanjar, M Diab-Assaf, F Caldefie-Chezet… - International journal of …, 2021 - mdpi.com
The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …

Is it time to start transitioning from 2D to 3D cell culture?

C Jensen, Y Teng - Frontiers in molecular biosciences, 2020 - frontiersin.org
Cell culture is an important and necessary process in drug discovery, cancer research, as
well as stem cell study. Most cells are currently cultured using two-dimensional (2D) …

Synthetic hydrogels: Synthesis, novel trends, and applications

USK Madduma‐Bandarage… - Journal of Applied …, 2021 - Wiley Online Library
Hydrogels have been generated and explored for use in various applications. The main
objective of this comprehensive review is to collate the fundamental concepts of hydrogels …

Hydrogels classification according to the physical or chemical interactions and as stimuli-sensitive materials

M Bustamante-Torres, D Romero-Fierro… - Gels, 2021 - mdpi.com
Hydrogels are attractive biomaterials with favorable characteristics due to their water uptake
capacity. However, hydrogel properties are determined by the cross-linking degree and …

Versatility of hydrogels: from synthetic strategies, classification, and properties to biomedical applications

Z Ahmad, S Salman, SA Khan, A Amin, ZU Rahman… - Gels, 2022 - mdpi.com
Hydrogels are three-dimensional, cross-linked, and supramolecular networks that can
absorb significant volumes of water. Hydrogels are one of the most promising biomaterials in …

A comprehensive review on collagen type I development of biomaterials for tissue engineering: From biosynthesis to bioscaffold

IN Amirrah, Y Lokanathan, I Zulkiflee, MFMR Wee… - Biomedicines, 2022 - mdpi.com
Collagen is the most abundant structural protein found in humans and mammals, particularly
in the extracellular matrix (ECM). Its primary function is to hold the body together. The …

Smart hydrogels in tissue engineering and regenerative medicine

S Mantha, S Pillai, P Khayambashi, A Upadhyay… - Materials, 2019 - mdpi.com
The field of regenerative medicine has tremendous potential for improved treatment
outcomes and has been stimulated by advances made in bioengineering over the last few …

Biomedical applications of hydrogels in drug delivery system: An update

P Kesharwani, A Bisht, A Alexander, V Dave… - Journal of Drug Delivery …, 2021 - Elsevier
Conventional drug delivery system generally deals with the issues involving repeated
dosing and systemic toxicities. Since few decades, hydrogels have played a significant role …

Commercial hydrogels for biomedical applications

SH Aswathy, U Narendrakumar, I Manjubala - Heliyon, 2020 - cell.com
Hydrogels are polymeric networks having the ability to absorb a large volume of water.
Flexibility, versatility, stimuli-responsive, soft structure are the advantages of hydrogels. It is …

Hydrogel scaffolds for tissue engineering: the importance of polymer choice

CD Spicer - Polymer Chemistry, 2020 - pubs.rsc.org
Hydrogel scaffolds that can repair or regrow damaged biological tissue have great potential
for the treatment of injury and disease. These biomaterials are widely used in the tissue …