The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and
regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point …

Troponin (Tn) is a critical regulator of muscle contraction in cardiac muscle. Mutations in Tn
subunits are associated with hypertrophic, dilated and restrictive cardiomyopathies …

Troponin I (TnI) is the inhibitory subunit of the troponin complex in the sarcomeric thin
filament of striated muscle and plays a central role in the calcium regulation of contraction …

Heart failure (HF) presents a significant clinical challenge, with current treatments mainly
easing symptoms without stop** disease progression. The targeting of calcium (Ca2+) …

Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated
with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is …

Myofilament calcium sensitivity is an often-used indicator of cardiac muscle function, often
assessed in disease states such as hypertrophic cardiomyopathy (HCM) and dilated …

Cardiomyopathies represent a heterogeneous group of diseases that negatively affect heart
function. Primary cardiomyopathies specifically target the myocardium, and may arise from …

Troponin is a heterotrimeric Ca2+-binding protein that has a well-established role in
regulating striated muscle contraction. However, mounting evidence points to novel cellular …

Matrix nanotopographical cues are known to regulate the structure and function of somatic
cells derived from human pluripotent stem cell (hPSC) sources. High-throughput …