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[HTML][HTML] Mechanisms of IGF-1-mediated regulation of skeletal muscle hypertrophy and atrophy
Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …
The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia
As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …
Ancestry-inclusive dog genomics challenges popular breed stereotypes
Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …
Mechanisms regulating skeletal muscle growth and atrophy
Skeletal muscle mass increases during postnatal development through a process of
hypertrophy, ie enlargement of individual muscle fibers, and a similar process may be …
hypertrophy, ie enlargement of individual muscle fibers, and a similar process may be …
Correlation between insulin-like growth factor 1 gene expression and fennel (Foeniculum vulgare) seed powder consumption in muscle of sheep
It has been shown that addition of fennel in the diets of domestic animals has positive and
beneficial effects on growth and meat production traits. Thus, the purpose of current study …
beneficial effects on growth and meat production traits. Thus, the purpose of current study …
The growth hormone receptor: mechanism of receptor activation, cell signaling, and physiological aspects
The growth hormone receptor (GHR), although most well known for regulating growth, has
many other important biological functions including regulating metabolism and controlling …
many other important biological functions including regulating metabolism and controlling …
JAK/STAT–emerging players in metabolism
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is
crucial for transducing signals from a variety of metabolically relevant hormones and …
crucial for transducing signals from a variety of metabolically relevant hormones and …
Glucocorticoid-induced skeletal muscle atrophy
Many pathological states characterized by muscle atrophy (eg, sepsis, cachexia, starvation,
metabolic acidosis and severe insulinopenia) are associated with an increase in circulating …
metabolic acidosis and severe insulinopenia) are associated with an increase in circulating …
Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice
T Sasako, T Umehara, K Soeda, K Kaneko… - Nature …, 2022 - nature.com
Aging is considered to be accelerated by insulin signaling in lower organisms, but it
remained unclear whether this could hold true for mammals. Here we show that mice with …
remained unclear whether this could hold true for mammals. Here we show that mice with …
Diabetic muscular atrophy: molecular mechanisms and promising therapies
Y Shen, M Li, K Wang, G Qi, H Liu, W Wang… - Frontiers in …, 2022 - frontiersin.org
Diabetes mellitus (DM) is a typical chronic disease that can be divided into 2 types,
dependent on insulin deficiency or insulin resistance. Incidences of diabetic complications …
dependent on insulin deficiency or insulin resistance. Incidences of diabetic complications …