PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
RNA granules: functional compartments or incidental condensates?
RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …
RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond
A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in
addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm …
addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm …
PIWI-interacting small RNAs: the vanguard of genome defence
PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that form the
piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …
piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …
RISC assembly: Coordination between small RNAs and Argonaute proteins
H Kobayashi, Y Tomari - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …
piRNAs: from biogenesis to function
EM Weick, EA Miska - Development, 2014 - journals.biologists.com
Distinguishing self from non-self plays a crucial role in safeguarding the germlines of
metazoa from mobile DNA elements. Since their discovery less than a decade ago, Piwi …
metazoa from mobile DNA elements. Since their discovery less than a decade ago, Piwi …
mRNP granules: assembly, function, and connections with disease
JR Buchan - RNA biology, 2014 - Taylor & Francis
Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that
harbor non-translating mRNAs bound by various proteins that regulate mRNA translation …
harbor non-translating mRNAs bound by various proteins that regulate mRNA translation …
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes
Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that
suppress transposons and enable gamete maturation. Mammalian transposon-silencing …
suppress transposons and enable gamete maturation. Mammalian transposon-silencing …
Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility
B Stallmeyer, C Bühlmann, R Stakaitis, AK Dicke… - Nature …, 2024 - nature.com
Abstract piRNAs are crucial for transposon silencing, germ cell maturation, and fertility in
male mice. Here, we report on the genetic landscape of piRNA dysfunction in humans and …
male mice. Here, we report on the genetic landscape of piRNA dysfunction in humans and …
PIWI-interacting RNAs: from generation to transgenerational epigenetics
Small-RNA-guided gene regulation is a recurring theme in biology. Animal germ cells are
characterized by an intriguing small-RNA-mediated gene-silencing mechanism known as …
characterized by an intriguing small-RNA-mediated gene-silencing mechanism known as …