Solute carrier (SLC) transporters meditate many essential physiological functions, including
nutrient uptake, ion influx/efflux, and waste disposal. In its protective role against tumors and …

Bicarbonate plays a fundamental role in the cell pH status in all organisms. In autotrophs,
HCO3− may further contribute to carbon concentration mechanisms (CCM). This is …

Breast cancer heterogeneity in histology and molecular subtype influences metabolic and
proliferative activity and hence the acid load on cancer cells. We hypothesized that acid …

Protein-tyrosine phosphatases (PTPs) counteract protein tyrosine phosphorylation and
cooperate with receptor-tyrosine kinases in the regulation of cell signaling. PTPs need to …

Regulation of physiological pH is integral for proper whole body and cellular function, and
disruptions in pH homeostasis can be both a cause and effect of disease. In light of this …

The availability of CO2 is one of the restrictions on aquatic photosynthesis. Solute carrier
(SLC) 4-2, a plasma membrane HCO3–transporter has previously been identified in the …

Increased metabolism and insufficient blood supply cause acidic waste product
accumulation in solid cancers. During carcinogenesis, cellular acid extrusion is upregulated …

Tilapia is a group of originally fresh water species, some of which can be tolerate a wide
range of salinities and can be cultured in estuaries or brackish water ponds in polyculture …

The bicarbonate ion has a fundamental role in vital systems. Impaired bicarbonate transport
leads to various diseases, including immune disorders, cystic fibrosis, tumorigenesis, kidney …

In recent decades, the scientific community has seen an increased interest in rigor and
reproducibility. In 2017, concerns about methodological thoroughness and reporting …