Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

Introduction Modern drug discovery is generally accessed by useful information from
previous large databases or uncovering novel data. The lack of biological and/or chemical …

The cysteine proteases, cruzain and Tbr CATL (rhodesain), are therapeutic targets for
Chagas disease and Human African Trypanosomiasis, respectively. Among the known …

Cruzipains are the main papain-like cysteine proteases of Trypanosoma cruzi, the protozoan
parasite that causes Chagas disease. Encoded by a multigenic family, previous studies …

Introduction Chagas disease (CD) imposes social and economic burdens, yet the available
treatments have limited efficacy in the disease's chronic phase and cause serious adverse …

Twenty different infectious disorders induced by bacteria, viruses, and parasites are
categorized as neglected tropical diseases (NTDs) by WHO. The severity of chagas disease …

Chagas disease is a disease that is emerging in North America and Europe countries.
Benznidazole is the main drug available, but it has high toxicity and low efficacy in the …

Trypanosoma cruzi is a parasite that infects about 6–7 million people worldwide, mostly in
Latin America, causing Chagas disease. Cruzain, the main cysteine protease of T. cruzi, is a …

Chagas disease is a neglected tropical disease, endemic in Latin America and caused by
the protozoan parasite Trypanosoma cruzi. Available treatments show low cure efficacy …

Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi that endangers almost 70 million people worldwide. The only two drugs …