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Harnessing EHR data for health research
With the increasing availability of rich, longitudinal, real-world clinical data recorded in
electronic health records (EHRs) for millions of patients, there is a growing interest in …
electronic health records (EHRs) for millions of patients, there is a growing interest in …
Neuroimmune contributions to Alzheimer's disease: a focus on human data
The past decade has seen the convergence of a series of new insights that arose from
genetic and systems analyses of Alzheimer's disease (AD) with a wealth of epidemiological …
genetic and systems analyses of Alzheimer's disease (AD) with a wealth of epidemiological …
Leveraging electronic health records and knowledge networks for Alzheimer's disease prediction and sex-specific biological insights
Identification of Alzheimer's disease (AD) onset risk can facilitate interventions before
irreversible disease progression. We demonstrate that electronic health records from the …
irreversible disease progression. We demonstrate that electronic health records from the …
[HTML][HTML] Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer's disease
Translating human genetic findings (genome-wide association studies [GWAS]) to
pathobiology and therapeutic discovery remains a major challenge for Alzheimer's disease …
pathobiology and therapeutic discovery remains a major challenge for Alzheimer's disease …
Drug repurposing for Alzheimer's disease from 2012–2022—A 10-year literature review
Background: Alzheimer's disease (AD) is a debilitating neurodegenerative condition with
few treatment options available. Drug repurposing studies have sought to identify existing …
few treatment options available. Drug repurposing studies have sought to identify existing …
[HTML][HTML] Brain health in diverse settings: How age, demographics and cognition shape brain function
Diversity in brain health is influenced by individual differences in demographics and
cognition. However, most studies on brain health and diseases have typically controlled for …
cognition. However, most studies on brain health and diseases have typically controlled for …
Demographic reporting across a decade of neuroimaging: a systematic review
E Sterling, H Pearl, Z Liu, JW Allen… - Brain Imaging and …, 2022 - Springer
Diversity of participants in biomedical research with respect to race, ethnicity, and biological
sex is crucial, particularly given differences in disease prevalence, recovery, and survival …
sex is crucial, particularly given differences in disease prevalence, recovery, and survival …
Similarities and differences in Alzheimer's dementia comorbidities in racialized populations identified from electronic medical records
Background Alzheimer's dementia (AD) is a neurodegenerative disease that is
disproportionately prevalent in racially marginalized individuals. However, due to research …
disproportionately prevalent in racially marginalized individuals. However, due to research …
Uncovering Important Diagnostic Features for Alzheimer's, Parkinson's and Other Dementias Using Interpretable Association Mining Methods
Alzheimer's Disease and Related Dementias (ADRD) afflict almost 7 million people in the
USA alone. The majority of research in ADRD is conducted using post-mortem samples of …
USA alone. The majority of research in ADRD is conducted using post-mortem samples of …
Few shot learning for phenotype-driven diagnosis of patients with rare genetic diseases
There are more than 7,000 rare diseases, some affecting 3,500 or fewer patients in the US.
Due to clinicians' limited experience with such diseases and the heterogeneity of clinical …
Due to clinicians' limited experience with such diseases and the heterogeneity of clinical …