Structural and functional remodeling of neural networks in β-amyloid driven hippocampal hyperactivity

J Li, Y Liu, C Yin, Y Zeng, Y Mei - Ageing Research Reviews, 2024 - Elsevier
Early detection of Alzheimer's disease (AD) is essential for improving the patients outcomes
and advancing our understanding of disease, allowing for timely intervention and treatment …

Deep brain stimulation of thalamic nucleus reuniens promotes neuronal and cognitive resilience in an Alzheimer's disease mouse model

S Shoob, N Buchbinder, O Shinikamin, O Gold… - Nature …, 2023 - nature.com
The mechanisms that confer cognitive resilience to Alzheimer's Disease (AD) are not fully
understood. Here, we describe a neural circuit mechanism underlying this resilience in a …

Linking activity dyshomeostasis and sleep disturbances in Alzheimer disease

I Slutsky - Nature Reviews Neuroscience, 2024 - nature.com
The presymptomatic phase of Alzheimer disease (AD) starts with the deposition of amyloid-β
in the cortex and begins a decade or more before the emergence of cognitive decline. The …

A therapeutic small molecule enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice

X Wei, JJ Campagna, B Jagodzinska, D Wi… - Proceedings of the …, 2024 - pnas.org
Brain rhythms provide the timing for recruitment of brain activity required for linking together
neuronal ensembles engaged in specific tasks. The γ-oscillations (30 to 120 Hz) orchestrate …

The Role of Epileptic Activity in Alzheimer's Disease

TS Chen, MC Lai, WP Hong… - American Journal of …, 2024 - journals.sagepub.com
Alzheimer's disease (AD) is the most common cause of dementia. Epileptic seizures or
epileptic activity have been detected in AD, and people with epilepsy have a higher risk of …

Gene Expression Signatures of Immaturity, Decreased pH, and Neural Hyperexcitation in the Hippocampus of Alzheimer's Disease Model Mice

S Naganishi, H Hagihara… - …, 2025 - Wiley Online Library
Aims Alzheimer's disease (AD) is a leading cause of dementia, with increasing prevalence.
Mutations in genes like MAPT, PSEN1, and PSEN2 are risk factors, leading to the …

Anti‐epileptic drug use and subsequent degenerative dementia occurrence

N Ikegaya, H Nakamura, Y Takayama… - … Research & Clinical …, 2024 - Wiley Online Library
INTRODUCTION The use of anti‐epileptic drugs (AEDs) in degenerative dementia (DD)
remains uncertain. We aimed to evaluate the association of early AED administration with …

A therapeutic small molecule lead enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice

X Wei, JJ Campagna, B Jagodzinska, D Wi, W Cohn… - bioRxiv, 2023 - biorxiv.org
Brain rhythms provide the timing and concurrence of brain activity required for linking
together neuronal ensembles engaged in specific tasks. In particular, the γ-oscillations (30 …

Deregulation of Melatonin Receptors and Differential Modulation of After‐Hyperpolarization and Ih Currents Using Melatonin Treatment Due to Amyloid‐β‐Induced …

MJ Eslamizade, F Saffarzadeh… - Cell Biochemistry …, 2024 - Wiley Online Library
Treatment with melatonin is routinely prescribed for its potent antioxidant and cognitive‐
promoting effects, nevertheless, it has yet to find neuromodulatory effects in normal and …

Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer's Disease Pathogenesis

DR Tabuena, SS Jang, B Grone, O Yip, EA Aery Jones… - bioRxiv, 2023 - biorxiv.org
The impact of apolipoprotein E4 (apoE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on neuronal function remains unclear. We investigated this by examining …