Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents
as a hypermetabolic response to potent volatile anesthetic gases such as halothane …

It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …

The endoplasmic reticulum (ER) as an intracellular Ca2+ store not only sets up cytosolic
Ca2+ signals, but, among other functions, also assembles and folds newly synthesized …

Our understanding of the underlying mechanisms of Ca2+ signaling as well as our
appreciation for its ubiquitous role in cellular processes has been rapidly advanced, in large …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

Background—Familial polymorphic ventricular tachycardia is an autosomal-dominant,
inherited disease with a relatively early onset and a mortality rate of≈ 30% by the age of 30 …

Calcium has an established role in the normal homeostasis of mammalian skin and serves
as a modulator in keratinocyte proliferation and differentiation. Gradients of calcium …

The action of thyroid hormones (THs) in the brain is strictly regulated, since these hormones
play a crucial role in the development and physiological functioning of the central nervous …

We characterized an activation mechanism of the human LTRPC2 protein, a member of the
transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates …

Capacitative Ca2+ entry involves the regulation of plasma membrane Ca2+ channels by the
filling state of intracellular Ca2+ stores in the endoplasmic reticulum (ER). Several theories …