Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …

Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and
pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target …

Abstract Antidepressants targeting Na+/Cl−-coupled neurotransmitter uptake define a key
therapeutic strategy to treat clinical depression and neuropathic pain. However, identifying …

The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Abstract Na+/Cl--dependent transporters terminate synaptic transmission by using
electrochemical gradients to drive the uptake of neurotransmitters, including the biogenic …

The SLC6 family of secondary active transporters are integral membrane solute carrier
proteins characterized by the Na+-dependent translocation of small amino acid or amino …

In monoaminergic neurons, the vesicular transporters and the plasma membrane
transporters operate in a relay. Amphetamine and its congeners target this relay to elicit their …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …

Cystinuria is a primary inherited aminoaciduria caused by mutations in the genes that
encode the two subunits (neutral and basic amino acid transport protein rBAT and b (0,+) …