Polyphenols: benefits to the cardiovascular system in health and in aging

S Khurana, K Venkataraman, A Hollingsworth, M Piche… - Nutrients, 2013 - mdpi.com
Numerous studies have demonstrated the importance of naturally occurring dietary
polyphenols in promoting cardiovascular health and emphasized the significant role these …

Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases

QY Eng, PV Thanikachalam, S Ramamurthy - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance The compound epigallocatechin-3-gallate (EGCG), the
major polyphenolic compound present in green tea [Camellia sinensis (Theaceae], has …

Network medicine framework shows that proximity of polyphenol targets and disease proteins predicts therapeutic effects of polyphenols

IF do Valle, HG Roweth, MW Malloy, S Moco, D Barron… - Nature Food, 2021 - nature.com
Polyphenols, natural products present in plant-based foods, play a protective role against
several complex diseases through their antioxidant activity and by diverse molecular …

Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations

JJ Peterson, JT Dwyer, PF Jacques… - Nutrition …, 2012 - academic.oup.com
Twenty publications from twelve prospective cohorts have evaluated associations between
flavonoid intakes and incidence or mortality from cardiovascular disease (CVD) among …

Protective role of epigallocatechin-3-gallate in health and disease: a perspective

A Chowdhury, J Sarkar, T Chakraborti… - Biomedicine & …, 2016 - Elsevier
Tea is the most popular beverages all over the world. Polyphenols are found ubiquitously in
tea leaves and their regular consumption has been associated with a reduced risk of a …

Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome

A Basu, M Du, K Sanchez, MJ Leyva, NM Betts… - Nutrition, 2011 - Elsevier
OBJECTIVE: Green tea (Camellia sinensis) has shown to exert cardioprotective benefits in
observational studies. The objective of this clinical trial was to assess the effects of green tea …

Potential benefits of green tea polyphenol EGCG in the prevention and treatment of vascular inflammation in rheumatoid arthritis

S Riegsecker, D Wiczynski, MJ Kaplan, S Ahmed - Life sciences, 2013 - Elsevier
Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints in which systemic
overproduction of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis …

Advances in the anti-atherosclerotic mechanisms of epigallocatechin gallate

Y Liu, Y Long, J Fang, G Liu - Nutrients, 2024 - mdpi.com
Atherosclerosis (AS) is a common clinical sickness and the major pathological basis of
ischemic cardiocerebrovascular diseases (CCVDs). The pathogenesis of AS involves a …

Epigallocatechin gallate suppresses inflammation in human coronary artery endothelial cells by inhibiting NF-κB

AT Reddy, SP Lakshmi, EM Prasad… - Life Sciences, 2020 - Elsevier
The endothelium is a critical regulator of vascular homeostasis, controlling vascular tone
and permeability as well as interactions of leukocytes and platelets with blood vessel walls …

EGCG prevents PCB-126-induced endothelial cell inflammation via epigenetic modifications of NF-κB target genes in human endothelial cells

D Liu, JT Perkins, B Hennig - The Journal of nutritional biochemistry, 2016 - Elsevier
Anti-inflammatory polyphenols, such as epigallocatechin-3-gallate (EGCG), have been
shown to protect against the toxicity of environmental pollutants. It is well known that …