Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure

M Van Bodegom, JR Homberg… - Frontiers in cellular …, 2017 - frontiersin.org
Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective

V Glover, KJ O'Donnell, TG O'Connor… - Development and …, 2018 - cambridge.org
There is clear evidence that the mother's stress, anxiety, or depression during pregnancy
can alter the development of her fetus and her child, with an increased risk for later …

Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health

O Babenko, I Kovalchuk, GAS Metz - Neuroscience & Biobehavioral …, 2015 - Elsevier
Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …

Epigenetic responses and the developmental origins of health and disease

D Goyal, SW Limesand, R Goyal - Journal of Endocrinology, 2019 - joe.bioscientifica.com
Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …

Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress

GE Hodes, ML Pfau, I Purushothaman… - Journal of …, 2015 - Soc Neuroscience
Depression and anxiety disorders are more prevalent in females, but the majority of
research in animal models, the first step in finding new treatments, has focused …

Epigenetic basis of mental illness

EJ Nestler, CJ Peña, M Kundakovic… - The …, 2016 - journals.sagepub.com
Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …

Prenatal stress and its effects on the fetus and the child: possible underlying biological mechanisms

V Glover - Perinatal programming of neurodevelopment, 2015 - Springer
Many prospective studies have shown that if a mother is depressed, anxious or stressed
while pregnant, this increases the risk for her child having a wide range of adverse …

Glucocorticoids and fetal programming part 2: mechanisms

VG Moisiadis, SG Matthews - Nature Reviews Endocrinology, 2014 - nature.com
The lifelong health of an individual is shaped during critical periods of development. The
fetus is particularly susceptible to internal and external stimuli, many of which can alter …

Transfer of maternal psychosocial stress to the fetus

F Rakers, S Rupprecht, M Dreiling, C Bergmeier… - Neuroscience & …, 2020 - Elsevier
Psychosocial maternal stress experienced during different vulnerable periods throughout
gestation is thought to increase the individual's risk to develop neuropsychiatric …

Mechanisms underlying the effects of prenatal psychosocial stress on child outcomes: beyond the HPA axis

R Beijers, JK Buitelaar, C de Weerth - European child & adolescent …, 2014 - Springer
Accumulating evidence from preclinical and clinical studies indicates that maternal
psychosocial stress and anxiety during pregnancy adversely affect child outcomes …