[HTML][HTML] Genome-wide RNA sequencing of human trabecular meshwork cells treated with TGF-β1: relevance to pseudoexfoliation glaucoma

AW Roodnat, B Callaghan, C Doyle, M Henry… - Biomolecules, 2022 - mdpi.com
Pseudoexfoliation glaucoma (XFG) is an aggressive form of secondary open angle
glaucoma, characterised by the production of exfoliation material and is estimated to affect …

Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

Z Wu, X Yu, S Zhang, Y He, W Guo - Frontiers in Immunology, 2022 - frontiersin.org
Circular RNAs (circRNAs) are a new series of noncoding RNAs (ncRNAs) that have been
reported to be expressed in eukaryotic cells and have a variety of biological functions in the …

The role of metalloproteinases and their tissue inhibitors on ocular diseases: focusing on potential mechanisms

M Caban, K Owczarek, U Lewandowska - International Journal of …, 2022 - mdpi.com
Eye diseases are associated with visual impairment, reduced quality of life, and may even
lead to vision loss. The efficacy of available treatment of eye diseases is not satisfactory. The …

[HTML][HTML] Astragaloside IV attenuates ocular hypertension in a mouse model of TGFβ2 induced primary open angle glaucoma

RB Kasetti, P Maddineni, B Kodati… - International Journal of …, 2021 - mdpi.com
Elevated intraocular pressure (IOP) is a major risk factor in develo** primary open angle
glaucoma (POAG), which is the most common form of glaucoma. Transforming growth factor …

Glaucoma patients have a lower abundance of butyrate-producing taxa in the gut

JE Vergroesen, ZA Jarrar, S Weiss… - … & Visual Science, 2024 - iovs.arvojournals.org
Purpose: Glaucoma is an eye disease that is the most common cause of irreversible
blindness worldwide. It has been suggested that gut microbiota can produce reactive …

Gene therapies and gene product-based drug candidates for normalizing and preserving tissue functions in animal models of ocular hypertension and glaucoma

NA Sharif - Molecular Aspects of Medicine, 2023 - Elsevier
More than 76 million people worldwide are afflicted with the neurodegenerative eye
diseases described and grouped together as glaucoma. A common feature amongst the …