The bewildering antitubercular action of pyrazinamide
Pyrazinamide (PZA) is a cornerstone antimicrobial drug used exclusively for the treatment of
tuberculosis (TB). Due to its ability to shorten drug therapy by 3 months and reduce disease …
tuberculosis (TB). Due to its ability to shorten drug therapy by 3 months and reduce disease …
Pyrazinecarboxylic acid and analogs: Highly efficient co-catalysts in the metal-complex-catalyzed oxidation of organic compounds
The development of new metal complex catalysts and efficient protocols for the mild and
selective oxidation of alkanes, arenes, olefins, alcohols, and other organic substrates is a …
selective oxidation of alkanes, arenes, olefins, alcohols, and other organic substrates is a …
Antiinfectives targeting enzymes and the proton motive force
There is a growing need for new antibiotics. Compounds that target the proton motive force
(PMF), uncouplers, represent one possible class of compounds that might be developed …
(PMF), uncouplers, represent one possible class of compounds that might be developed …
Tuning the composition of AuPt bimetallic nanoparticles for antibacterial application
Y Zhao, C Ye, W Liu, R Chen… - Angewandte Chemie …, 2014 - Wiley Online Library
We show that bimetallic nanoparticles (NPs) of AuPt without any surface modification are
potent antibiotic reagents, while pure Au NPs or pure Pt NPs display no antibiotic activities …
potent antibiotic reagents, while pure Au NPs or pure Pt NPs display no antibiotic activities …
Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis
ABSTRACT MmpL3, a resistance-nodulation-division (RND) superfamily transporter, has
been implicated in the formation of the outer membrane of Mycobacterium tuberculosis; …
been implicated in the formation of the outer membrane of Mycobacterium tuberculosis; …
The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress
Targeting respiration and ATP synthesis has received strong interest as a new strategy for
combatting drug-resistant Mycobacterium tuberculosis. Mycobacteria employ a respiratory …
combatting drug-resistant Mycobacterium tuberculosis. Mycobacteria employ a respiratory …
Sterilizing activities of novel combinations lacking first-and second-line drugs in a murine model of tuberculosis
K Williams, A Minkowski, O Amoabeng… - Antimicrobial agents …, 2012 - journals.asm.org
Novel oral regimens composed of new drugs with potent activity against Mycobacterium
tuberculosis and no cross-resistance with existing agents are needed to shorten and simplify …
tuberculosis and no cross-resistance with existing agents are needed to shorten and simplify …
The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd
Mycobacterial energy metabolism currently attracts strong attention as new target space for
development of anti-tuberculosis drugs. The imidazopyridine Q203 targets the cytochrome …
development of anti-tuberculosis drugs. The imidazopyridine Q203 targets the cytochrome …
Targeting bacterial energetics to produce new antimicrobials
From the war on drug resistance, through cancer biology, even to agricultural and
environmental protection: there is a huge demand for rapid and effective solutions to control …
environmental protection: there is a huge demand for rapid and effective solutions to control …
[HTML][HTML] ATP synthase in mycobacteria: special features and implications for a function as drug target
ATP synthase is a ubiquitous enzyme that is largely conserved across the kingdoms of life.
This conservation is in accordance with its central role in chemiosmotic energy conversion, a …
This conservation is in accordance with its central role in chemiosmotic energy conversion, a …