Edema formation following traumatic spinal cord injury (SCI) exacerbates secondary injury,
and the severity of edema correlates with worse neurological outcome in human patients. To …

This sco** review systematically reviewed relevant research to summarize the literature
addressing the significance of monitoring spinal cord perfusion pressure (SCPP) in acute …

Abstract Aquaporin-4 (AQP-4) is an aquaporin composed of six helical transmembrane
domains and two highly conserved ASN-pro-ALA (NPA) motifs. It is strongly expressed in …

It has recently been shown that substance P (SP) plays a major role in the secondary injury
process following traumatic brain injury (TBI), particularly with respect to neuroinflammation …

Raised intrathecal pressure (ITP) after traumatic spinal cord injury (SCI) is a critically
important aspect of injury development that may result in significantly greater tissue damage …

Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous
system (CNS). A number of previous studies described the cellular expression sites and …

Over 80 years has passed since the discovery of substance P (SP), and a variety of peptides
of the tachykinin (TK) family have been found and investigated. SP, neurokinin A (NKA), and …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive motor neuron loss. Evidence suggests that mitochondrial dysfunction …

The neuropeptide substance P (SP) has been implicated in the disruption of the blood-brain
barrier (BBB) and development of cerebral edema in acute brain injury. Cerebral edema …

Hemisection of the spinal cord at C 2 eliminates ipsilateral descending drive to the phrenic
nucleus and causes hemidiaphragmatic paralysis in rats. Phrenic nerve (PhN) or …