Phoenix dactylifera L.: An Overview of Phytochemical Constituents and Impact on Women's Health

EM AbouZeid, AH Afifi, RA Hussei… - Chemistry & …, 2024 - Wiley Online Library
Phoenix dactylifera L.(date palm) is the most significant member of the palm family
(Arecaceae), particularly in the Middle East and Arab World. It is a valuable source of both …

Approaches to Enhance Sugar Content in Foods: Is the Date Palm Fruit a Natural Alternative to Sweeteners?

E Sayas-Barberá, C Paredes, M Salgado-Ramos… - Foods, 2023 - mdpi.com
The current levels of added sugars in processed foods impact dental health and contribute
to a range of chronic non-communicable diseases, such as overweight, obesity, metabolic …

In-silico investigation of RPS6KB1 associated cancer inhibitor: a drug repurposing study

S Rajendrasozhan, I Ahmad… - Journal of …, 2024 - Taylor & Francis
The ribosomal protein S6 kinase beta-1 (RPS6KB1), also known as p70S6 kinase, plays a
crucial role in various disease-related conditions such as diabetes, obesity, and cancer. Its …

Discovery of novel TACE inhibitors using graph convolutional network, molecular docking, molecular dynamics simulation, and Biological evaluation

M Yasir, J Park, ET Han, JH Han, WS Park, M Hassan… - Plos one, 2024 - journals.plos.org
The increasing utilization of deep learning models in drug repositioning has proven to be
highly efficient and effective. In this study, we employed an integrated deep-learning model …

Soluble and hydrolyzable phenolic compounds in date fruits (Phoenix dactylifera L.) by UPLC-QTOF-MS/MS and UPLC-DAD

MZ Alam, R Fristedt, R Landberg… - Journal of Food …, 2024 - Elsevier
Phenolic compounds in plant foods exist in soluble, hydrolyzable, and insoluble forms. This
study is the first to analyze both soluble (extracted using 80% methanol) and hydrolyzable …

Exploring the DPP IV inhibitory potential: molecular docking and dynamic simulations of pyridine-3-carboxylic acid and pyrrolidine-2-carboxylic acid analogs

HH Puranik, AB Thomas, KB Lokhande… - Journal of …, 2024 - Taylor & Francis
Diabetes mellitus remains a global challenge, with Type 2 Diabetes Mellitus (T2DM)
prevalence increasing from 4% to 6.4% in the past 30 years. Presently oral hypoglycaemic …

[HTML][HTML] Optimizing the leaf-to-bunch ratio in 'Mazafati'date trees by considering source-sink limitation and physiological-molecular responses

M Alikhani-Koupaei, A Khosravinejad - Journal of Agriculture and Food …, 2024 - Elsevier
The balance between carbon production and consumption is regulated by source and sink,
which can limit plant performance. When there is an imbalance between source and sink …

Unraveling the potential of Epicatechin gallate from crataegus oxyacantha in targeting aberrant cardiac Ca2+ signalling proteins: an in-depth in-silico investigation for …

J Praveen, M Anusuyadevi… - Journal of Biomolecular …, 2024 - Taylor & Francis
The cardiovascular sarcoplasmic reticulum (SR) calcium (Ca2+) ATPase is an imperative
determinant of cardiac functionality. In addition, anomalies in Ca2+ handling protein and …

Bioactivity predictions and virtual screening using machine learning predictive model

NF Siddiqui, P Vishwakarma, S Thakur… - Journal of …, 2024 - Taylor & Francis
Recently, there has been significant attention on machine learning algorithms for predictive
modeling. Prediction models for enzyme inhibitors are limited, and it is essential to account …

Discovery of 5‐(1‐benzyl‐1H‐imidazol‐4‐yl)‐1, 2, 4‐oxadiazole derivatives as novel RIPK1 inhibitors via structure‐based virtual screening

Y Yu, Y Hu, H Yan, X Zeng, H Yang… - Drug Development …, 2024 - Wiley Online Library
RIPK1 plays a key role in necroptosis and is associated with various inflammatory diseases.
Using structure‐based virtual screening, a novel hit with 5‐(1‐benzyl‐1H‐imidazol‐4‐yl)‐1 …