Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively
expressed on the surface of professional antigen-presenting cells (APCs), including …

Highlights•IL-10 inhibits T cell activation by suppressing APC function.•IL-10 suppresses
TLR-signaling in dendritic cells and monocytes/macrophages.•IL-10 suppresses IFNγ …

Efficient immune responses require regulated antigen presentation to CD4 T cells. IL-10
inhibits the ability of dendritic cells (DCs) and macrophages to stimulate antigen-specific …

The immune system initiates robust immune responses to defend against invading
pathogens or tumor cells and protect the body from damage, thus acting as a fortress of the …

Loss of IL-10 signaling in macrophages (Mφs) leads to inflammatory bowel disease (IBD).
Induced pluripotent stem cells (iPSCs) were generated from an infantile-onset IBD patient …

Francisella tularensis is an intracellular Gram-negative bacterium that causes life-
threatening tularemia. Although the prevalence of natural infection is low, F. tularensis …

Over the last decade, studies on the virulence of the highly pathogenic intracellular bacterial
pathogen Francisella tularensis have increased dramatically. The organism produces an …

Ubiquitin-mediated proteasomal degradation is a post-transcriptional protein modification
that is comprised of various components including the 76-amino acid protein ubiquitin (Ub) …

Piscirickettsia salmonis is a facultative intracellular bacterium that causes the disease called
“salmon rickettsial syndrome”. Attempts to control this disease have been unsuccessful …

Highlights•MARCH E3 ubiquitin ligases regulate key immunoreceptors.•New findings
highlight breadth and diversity of MARCH-mediated immune modulation.•Pathogens use …