Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

Consumption of adenosine triphosphate (ATP) by the heart can change dramatically as the
energetic demands increase from a period of rest to strenuous activity. Mitochondrial ATP …

Mitochondria are critical players involved in both cell life and death through multiple
pathways. Structural integrity, metabolism and function of mitochondria are regulated by …

Ca2+ transport across the inner membrane of mitochondria (IMM) is of major importance for
their functions in bioenergetics, cell death and signaling. It is therefore tightly regulated. It …

Regulation of mitochondrial free Ca2+ is critically important for cellular homeostasis. An
increase in mitochondrial matrix free Ca2+ concentration ([Ca2+] m) predisposes …

The authors propose a novel approach to a comprehensive evaluation of neuroprotective
effects using both in vitro and in vivo methods. This approach allows for the initial screening …

Mitochondrial dehydrogenases are differentially stimulated by Ca2+. Ca2+ has also diverse
regulatory effects on mitochondrial transporters and other enzymes. However, the …

Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-
Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing …

One of the most fascinating aspects of mitochondria is their remarkable ability to accumulate
and store large amounts of calcium in the presence of phosphate leading to mitochondrial …

Background Calcium signaling plays a key role in the regulation of multiple processes in
mammalian mitochondria, from cellular bioenergetics to the induction of stress-induced cell …