Antimicrobial resistance (AMR) is one of the most critical threats to global public health in the
21st century, causing a large number of deaths every year in both high-income and low-and …

Vaccination arguably remains the only long-term strategy to limit the spread of S. aureus
infections and its related antibiotic resistance. To date, however, all staphylococcal vaccines …

The pathobiont Staphylococcus aureus (Sa) induces nonprotective antibody imprints that
underlie ineffective staphylococcal vaccination. However, the mechanism by which Sa …

Develo** an effective Staphylococcus aureus (S. aureus) vaccine has been a challenging
endeavor, as demonstrated by numerous failed clinical trials over the years. In this study, we …

Staphylococcus aureus remains a leading global cause of bacterial infection-associated
mortality and has eluded prior vaccine development efforts. S. aureus α-toxin (Hla) is an …

Pathobionts have evolved many strategies to coexist with the host, but how immune evasion
mechanisms contribute to the difficulty of develo** vaccines against pathobionts is …

A path forward for Staphylococcus aureus vaccine development - PMC Skip to main content
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Forssman was a Swedish pathologist and microbiologist who, in the 1920s and 1930s
conducted a long series of experiments that led to unique insights into surface antigens of …

Purpose Staphylococcus aureus is a Gram-positive bacterium that most frequently acquires
antibiotic resistance. As an opportunistic pathogen, it can cause conditions such as …

During repeated virus exposure, pre-existing antibodies can mask viral epitopes by
competing with B cell receptors for antigen. Although this phenomenon has the potential to …