Recent advancements in small RNA sequencing have unveiled a previously hidden world of
regulatory small noncoding RNAs (sncRNAs) that extend beyond the well-studied small …

Abstract Crick's Central Dogma has been a foundational aspect of 20th century biology,
describing an implicit relationship governing the flow of information in biological systems in …

Abstract Background Direct RNA sequencing (dRNA-seq) on the Oxford Nanopore
Technologies (ONT) platforms can produce reads covering up to full-length gene transcripts …

Unlike coding genes, the number of lncRNA genes in organism genomes is relatively
proportional to organism complexity. From plants to humans, the tissues with highest …

The human genome project's lasting legacies are the emerging insights into human
physiology and disease, and the ascendance of biology as the dominant science of the 21st …

The dark genome, the nonprotein-coding part of the genome, is replete with long noncoding
RNAs (lncRNAs). These functionally versatile transcripts, with specific temporal and spatial …

In recent years, there has been increased focus on exploring the role the non-protein-coding
genome plays in Mendelian disorders. One class of particular interest is long non-coding …

Epigenetic modifications can alter the function of genes. The epigenetics changes are
caused by environmental effects, which lead to chemical modifications of the DNA or the …

Evolution and development are interrelated processes influenced by genomic, epigenetic,
and environmental factors. Epigenetic processes serve critical roles in development and …

Thomas Kuhn described the progress of science as comprising occasional paradigm shifts
separated by interludes of 'normal science'. The paradigm that has held sway since the …