[HTML][HTML] Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies
Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery and
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …
Emerging nanomedicines for anti-stromal therapy against desmoplastic tumors
Solid tumors, especially desmoplastic tumors, are characterized by a dense fibrotic stroma
composed of abundant cancer-associated fibroblasts and excessive extracellular matrix …
composed of abundant cancer-associated fibroblasts and excessive extracellular matrix …
Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti–PD-L1 immunotherapy
Anti–programmed cell death 1 ligand 1 (PD-L1) therapy is extraordinarily effective in select
patients with cancer. However, insufficient lymphocytic infiltration, weak T cell–induced …
patients with cancer. However, insufficient lymphocytic infiltration, weak T cell–induced …
Stromal modulation and treatment of metastatic pancreatic cancer with local intraperitoneal triple miRNA/siRNA nanotherapy
Nanomedicines achieve tumor-targeted delivery mainly through enhanced permeability and
retention (EPR) effect following intravenous (IV) administration. Unfortunately, the EPR effect …
retention (EPR) effect following intravenous (IV) administration. Unfortunately, the EPR effect …
Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury
Acute kidney injury (AKI) is characterized by a sudden decrease in renal function and
impacts growing number of people worldwide. RNA interference (RNAi) showed potential to …
impacts growing number of people worldwide. RNA interference (RNAi) showed potential to …
Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy
Combination of anticancer drugs with therapeutic microRNA (miRNA) has emerged as a
promising anticancer strategy. However, the promise is hampered by a lack of desirable …
promising anticancer strategy. However, the promise is hampered by a lack of desirable …
MUC4 mucin-a therapeutic target for pancreatic ductal adenocarcinoma
Introduction: Pancreatic cancer (PC) is characterized by mucin overexpression. MUC4 is the
most differentially overexpressed membrane-bound mucin that plays a functional role in …
most differentially overexpressed membrane-bound mucin that plays a functional role in …
Preferential siRNA delivery to injured kidneys for combination treatment of acute kidney injury
Acute kidney injury (AKI) is characterized by a sudden loss of renal function and is
associated with high morbidity and mortality. Tumor suppressor p53 and chemokine …
associated with high morbidity and mortality. Tumor suppressor p53 and chemokine …
Increased survival by pulmonary treatment of established lung metastases with dual STAT3/CXCR4 inhibition by siRNA nanoemulsions
Z Li, G Chen, L Ding, Y Wang, C Zhu, K Wang, J Li… - Molecular Therapy, 2019 - cell.com
Lung metastasis is a common and deadly occurrence in many types of solid tumors.
Chemokine receptor CXCR4 and transcription factor signal transducer and activator of …
Chemokine receptor CXCR4 and transcription factor signal transducer and activator of …
Intraperitoneal siRNA nanoparticles for augmentation of gemcitabine efficacy in the treatment of pancreatic cancer
Pancreatic ductal adenocarcinoma is a deadly disease with limited treatment options due to
late diagnosis and resistance to conventional chemotherapy. Among emerging therapeutic …
late diagnosis and resistance to conventional chemotherapy. Among emerging therapeutic …