In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

Ovarian age is classically considered the main cause of female reproductive infertility. In
women, the process proceeds as an ongoing decline in the primordial follicle stockpile and it …

Summary In our 24/7 well-lit world, it's easy to skip or delay sleep to work, study, and play.
However, our circadian rhythms are not easily fooled; the consequences of jet lag and shift …

The p53 family of proteins evolved from a common ancestor into three separate genes
encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each …

The transcription factor p63 guards genome integrity in the female germline, and its
mutations have been reported in patients with premature ovarian insufficiency (POI) …

Summary PERIOD (PER) and Casein Kinase 1δ regulate circadian rhythms through a
phosphoswitch that controls PER stability and repressive activity in the molecular clock …

CK1s are acidophilic serine/threonine kinases with multiple critical cellular functions; their
misregulation contributes to cancer, neurodegenerative diseases, and sleep phase …

The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the
regulation of several cellular functions, including cell cycle progression and cell death in …

The production of haploid gametes through meiosis is central to the principle of sexual
reproduction. The genetic diversity is further enhanced by exchange of genetic material …