Large language models (LLMs) have emerged as powerful tools in chemistry, significantly
impacting molecule design, property prediction, and synthesis optimization. This review …

The abundance of molecules on early Earth likely enabled a wide range of prebiotic
chemistry, with peptides playing a key role in the development of early life forms and the …

Peptide quantitative structure-activity relationship (pQSAR) is a specific extension of
traditional QSARs from small-molecule drugs to bioactive peptides. Since peptides are …

Calcitonin gene-related peptide (CGRP) has 37 amino acids. Initially, CGRP had
vasodilatory and nociceptive effects. As research progressed, evidence revealed that the …

Although antimicrobial peptides (AMPs) have highly desirable intrinsic characteristics in
their commercial product development as new antimicrobials, the limitations of AMPs from …

Given this special issue honors the scientific contributions of Dr. Ronald Borchardt, we
considered fitting to briefly discuss one of the areas where his research has made a great …

Osteoporosis is primarily driven by an imbalance between bone resorption and formation,
stemming from enhanced osteoclast activity during bone remodeling. At the crux of this …

Peptides can operate as therapeutic agents that sit within a privileged space between small
molecules and larger biologics. Despite examples of their potential to regulate receptors and …

Milk is a source of many valuable nutrients, including minerals, vitamins and proteins, with
an important role in adult health. Milk and dairy products naturally containing or with added …

Stapling rigidifies peptides through covalent linkages between amino acids. We introduce 2-
chloromethyl-6-cyanopyridine for non-symmetric stapling of N-terminal and internal …