Technological advances and breakthrough developments in the pharmaceutical field are
knocking at the door of the “undruggable” fortress with increasing insistence. Notably, the …

Over the past decade, protein–protein interactions (PPIs) have gone from being neglected
as 'undruggable'to being considered attractive targets for the development of therapeutics …

Highlights•One of the most widely adopted strategies for α-helix stabilisation is peptide
stapling.•Stapled peptides are highly promising therapeutic agents.•General design …

Transcription factors are key protein effectors in the regulation of gene transcription, and in
many cases their activity is regulated via a complex network of protein–protein interactions …

The design of new protein structures is challenging due to their vast sequence space and
the complexity of protein folding. Here, we report a new modular DNA-templated strategy to …

Conspectus Protein–protein interactions (PPIs) are ubiquitous in biological systems and
often misregulated in disease. As such, specific PPI modulators are desirable to unravel …

Protein secondary and tertiary structure mimics have served as model systems to probe
biophysical parameters that guide protein folding and as attractive reagents to modulate …

Protein tertiary structure mimetics are valuable tools to target large protein–protein
interaction interfaces. Here, we demonstrate a strategy for designing dimeric helix-hairpin …

Aberrant Ras signaling is linked to a wide spectrum of hyperproliferative diseases, and
components of the signaling pathway, including Ras, have been the subject of intense and …

The folding of natural proteins typically relies on hydrophobic packing, metal binding, or
disulfide bond formation in the protein core. Alternatively, a 3D structure can be defined by …