Protein glycosylation has a huge impact on biological processes in all domains of life. The
type of glycan present on a recombinant glycoprotein depends on protein intrinsic features …

The structure and post-translational processing of the SARS-CoV-2 spike glycoprotein (S) is
intimately associated with the function of the virus and of sterilising vaccines. The surface of …

A key barrier to the development of vaccines that induce broadly neutralizing antibodies
(bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic …

A major challenge to end the pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is to develop a broadly protective vaccine that elicits long-term …

The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity, whether
arisen naturally or through vaccination. Understanding the structure of the viral spike assists …

Broadly neutralizing antibodies (bnAbs) to the HIV envelope (Env) V2-apex region are
important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an …

Animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as
evidenced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …

The emergence of a polybasic cleavage motif for the protease furin in SARS-CoV-2 spike
has been established as a major factor for human viral transmission. The region N-terminal …

Among the current five Variants of Concern, infections caused by SARS-CoV-2 B. 1.617. 2
(Delta) variant are often associated with the greatest severity. Despite recent advances on …