Reductions play a key role in organic synthesis, producing chiral products with new
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …

Highlights•Discovery of new Cu 2+ radical oxidases with high activity and broad substrate
range.•Development of computational tool for engineering cofactor preference of alcohol …

The alkylation of amines with either alcohols or carboxylic acids represents a mild and safe
alternative to the use of genotoxic alkyl halides and sulfonate esters. Here we report two …

Amine dehydrogenases (AmDHs) catalyse the conversion of ketones into enantiomerically
pure amines at the sole expense of ammonia and hydride source. Guided by structural …

Amine dehydrogenase-catalyzed reductive amination of prochiral ketones with ammonia is
a promising method for the synthesis of optically pure amines in the pharmaceutical and fine …

Enantiomerically pure 1, 2-amino alcohols are important compounds due to their biological
activities and wide applications in chemical synthesis. In this work, we present two …

Artificial cascade reactions involving biocatalysts have demonstrated a tremendous potential
during the recent years. This review just focuses on selected examples of the last year and …

Nature's two redox cofactors, nicotinamide adenine dinucleotide (NAD+) and nicotinamide
adenine dinucleotide phosphate (NADP+), are held at different reduction potentials, driving …

Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum
substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum …

Cascade biotransformation of racemic alcohols to enantiopure amines is highly wanted in
pharmaceutical manufacturing but requires green and efficient solution. Here we developed …