Damage to genetic material represents a persistent and ubiquitous threat to genomic
stability. Once DNA damage is detected, a multifaceted signaling network is activated that …

We provide an overview of the functional interrelationship between genes and proteins
related to DNA repair by homologous recombination and cell cycle regulation in relation to …

RAD51 is one of six mitotic human homologs of the E. coli RecA protein (RAD51-Paralogs)
that play a central role in homologous recombination and repair of DNA double-strand …

Homologous recombination serves multiple roles in DNA repair that are essential for
maintaining genomic stability. We here describe RI-1, a small molecule that inhibits the …

DNA repair by homologous recombination is involved in maintaining genome stability.
Previous data report that wild‐type p53 suppresses homologous recombination and …

Fusion tyrosine kinases (FTKs) such as BCR/ABL, TEL/ABL, TEL/JAK2, TEL/PDGFβR,
TEL/TRKC (L), and NPM/ALK arise from reciprocal chromosomal translocations and cause …

Rad51 is an essential component of the homologous DNA repair pathway and has been
implicated as a determinant of cellular radiosensitivity. Gleevec is a relatively specific …

Recent developments in the use of small inhibitory RNA molecules (siRNAs) to inhibit
specific protein expression have highlighted the potential use of siRNA as a therapeutic …

Purpose: Recurrent glioblastoma multiforme (GBM) is characterized by resistance to
radiotherapy and chemotherapy and a poor clinical prognosis. In this study, we investigated …

BCR/ABL regulates cell proliferation, apoptosis, differentiation and adhesion. In addition,
BCR/ABL can induce resistance to cytostatic drugs and irradiation by modulation of DNA …