Adaptive therapy is a dynamic cancer treatment protocol that updates (or 'adapts') treatment
decisions in anticipation of evolving tumor dynamics. This broad term encompasses many …

At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp).
Inhibitors targeting various effectors within the ERKp have been developed and explored for …

Purpose: Acral melanoma is a rare subtype of melanoma that arises on the non–hair-
bearing skin of the palms, soles, and nail beds. In this study, we used single-cell RNA …

Understanding the evolutionary pathways to metastasis and resistance to immune-
checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present …

Standard-of-care treatment regimens have long been designed for maximal cell killing, yet
these strategies often fail when applied to metastatic cancers due to the emergence of drug …

Computational models can be applied to optimize treatment schedules and model treatment
responses in cancer therapy. In this Review, we provide an overview of such computational …

Adaptive therapy seeks to exploit intratumoral competition to avoid, or at least delay, the
emergence of therapy resistance in cancer. Motivated by promising results in prostate …

Gene expression states persist for varying lengths of time at the single-cell level, a
phenomenon known as gene expression memory. When cells switch states, losing memory …

Highlights•Cancer is a heterogeneous and evolving disease, yet most drugs are
administered to simply give the maximum dose.•Treatment scheduling currently ignores the …

Cancer is a complex disease and cancer cells typically harbor multiple genetic and
epigenetic alterations. Large-scale sequencing of patient-derived cancer samples has …