Background Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-
gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs …

Acid‐sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC) are both
members of the ENaC/degenerin family of amiloride‐sensitive Na+ channels. ASICs act as …

Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but
the underlying molecular mechanism remains unclear. We demonstrate here that acid …

Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in
recent years, through the implementation of targeted treatment and the introduction of …

Several bone conditions, eg, bone cancer, osteoporosis, and rheumatoid arthritis (RA), are
associated with a risk of develo** persistent pain. Increased osteoclast activity is often the …

Tissue acidification is associated with a variety of disease states, and acid-sensing ion
channels (ASICs) that can sense changes in pH have gained traction as possible …

Objectives Fibromyalgia is commonly considered a stress-related chronic pain disorder, and
daily stressors are known triggers. However, the relation between stress and pain …

Sensing acidosis is an important somatosensory function in responses to ischemia,
inflammation, and metabolic alteration. Accumulating evidence has shown that acidosis is …

Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin
(ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes …

The pH in the different tissues and organs of our body is kept within tight limits. Local pH
changes occur, however, temporarily under physiological conditions, as for example in …