Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity,
substrate specificity, and stability, they require mild conditions to react while prompting …

4 '-C-Ethynyl-β-d-arabino-and 4 '-C-ethynyl-2 '-deoxy-β-d-ribo-pentofuranosylpyrimidine and-
purine nucleosides were synthesized and evaluated for their in vitro anti-HIV activity. The …

We previously designed 1-(3-C-ethynyl-β-d-ribo-pentofuranosyl) uracil (EUrd) and its
cytosine congener (ECyd) as potential multifunctional antitumor nucleoside antimetabolites …

The stereocontrolled, de novo syntheses of β-2 '-deoxy-, α-2 '-deoxy-, β-3 '-deoxy-, and β-2 ',
3 '-dideoxyribonucleosides are described. Strategically protected ribose, arabinose, and …

The organic molecule 2-(1-phenyl-1-(pyridin-2-yl) ethyl)-6-(3-(1-phenyl-1-(pyridin-2-yl) ethyl)
phenyl) pyridine (H 3 L) has been designed, prepared, and employed to synthesize the …

A new synthesis route to α-l-threose nucleoside phosphonates via 2-O and 3-O selectively
protected l-threose is developed. The key intermediates 2-O-benzoyl-l-threonolactone and 1 …

A new and highly efficient ring-closing metathesis-based strategy was developed for the
synthesis of the cyclic urea 1, 3-diazepinone, presenting significant improvement upon …

Direct metal-free deoxygenation of highly active allylic alcohols catalyzed by a Brønsted acid
was achieved, which avoids tedious reaction steps and eliminates metal contamination. By …

The design and synthesis of potential antitumor antimetabolites 2 '-deoxy-2 '-
(hydroxylamino) uridine (15),-cytidine (19, 2 '-DHAC), and-adenosine (35), their …

Presented here is the first report on the ability of cerium (III) chloride to mediate high-yielding
and, oftentimes, highly diastereoselective additions of N-benzyl-α, N-dilithio …