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Sulfonyl fluorides as targets and substrates in the development of new synthetic methods
The advent of sulfur (vi)-fluoride exchange (SuFEx) processes as transformations with click-
like reactivity has invigorated research into electrophilic species featuring a sulfur–fluorine …
like reactivity has invigorated research into electrophilic species featuring a sulfur–fluorine …
Sulfur fluoride exchange
Click chemistry is a conceptual strategy to rapidly synthesize and discover functional
molecules. Sulfur fluoride exchange (SuFEx) is a click reaction that has revolutionized …
molecules. Sulfur fluoride exchange (SuFEx) is a click reaction that has revolutionized …
Covalent targeted radioligands potentiate radionuclide therapy
XY Cui, Z Li, Z Kong, Y Liu, H Meng, Z Wen, C Wang… - Nature, 2024 - nature.com
Targeted radionuclide therapy, in which radiopharmaceuticals deliver potent radionuclides
to tumours for localized irradiation, has addressed unmet clinical needs and improved …
to tumours for localized irradiation, has addressed unmet clinical needs and improved …
EnT-mediated N–S bond homolysis of a bifunctional reagent leading to aliphatic sulfonyl fluorides
JE Erchinger, R Hoogesteger, R Laskar… - Journal of the …, 2023 - ACS Publications
Sulfur (VI) fluoride exchange (SuFEx) gives rise to a plethora of high-valent sulfur linkages;
however, the availability of (aliphatic) sulfonyl fluoride manifolds lag behind, owing to the …
however, the availability of (aliphatic) sulfonyl fluoride manifolds lag behind, owing to the …
Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds
R Cannalire, S Pelliccia, L Sancineto… - Chemical Society …, 2021 - pubs.rsc.org
The late stage functionalization (LSF) of complex biorelevant compounds is a powerful tool
to speed up the identification of structure–activity relationships (SARs) and to optimize …
to speed up the identification of structure–activity relationships (SARs) and to optimize …
Advances in the construction of diverse SuFEx linkers
D Zeng, WP Deng, X Jiang - National Science Review, 2023 - academic.oup.com
Sulfur fluoride exchange (SuFEx), a new generation of click chemistry, was first presented by
Sharpless, Dong and co-workers in 2014. Owing to the high stability and yet efficient …
Sharpless, Dong and co-workers in 2014. Owing to the high stability and yet efficient …
The growing applications of SuFEx click chemistry
SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions,
geared towards the rapid and reliable assembly of functional molecules. This review …
geared towards the rapid and reliable assembly of functional molecules. This review …
Photoredox catalysis-enabled sulfination of alcohols and bromides
WP Carson II, PJ Sarver, NS Goudy… - Journal of the …, 2023 - ACS Publications
Sulfinates are important lynchpin intermediates in pharmaceutical production; however, their
synthesis via photoredox catalysis is challenging because of their facile oxidation. We …
synthesis via photoredox catalysis is challenging because of their facile oxidation. We …
Recent applications of click chemistry in drug discovery
X Jiang, X Hao, L **g, G Wu, D Kang… - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: Click chemistry has been exploited widely in the past to expedite lead
discovery and optimization. Indeed, Copper-catalyzed azide-alkyne cycloaddition (CuAAC) …
discovery and optimization. Indeed, Copper-catalyzed azide-alkyne cycloaddition (CuAAC) …
Photoredox catalytic radical fluorosulfonylation of olefins enabled by a bench-stable redox-active fluorosulfonyl radical precursor
Sulfonyl fluorides have attracted considerable and growing research interests from various
disciplines, which raises a high demand for novel and effective methods to access this class …
disciplines, which raises a high demand for novel and effective methods to access this class …