Gap junctions and cancer: communicating for 50 years
Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …
that loss of direct intercellular communication is commonly associated with cancer onset and …
[HTML][HTML] The connexin 43 C-terminus: A tail of many tales
Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …
communication between the cytosols of adjacent cells, create a unique cell signalling …
Connections with connexins: the molecular basis of direct intercellular signaling
Adjacent cells share ions, second messengers and small metabotes through intercellular
channels which are present in gap junctions. This type of intercellular communication …
channels which are present in gap junctions. This type of intercellular communication …
Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.
SH Chen, HD Shine, JC Goodman… - Proceedings of the …, 1994 - National Acad Sciences
The therapeutic efficacy of adenovirus-mediated herpes simplex virus thymidine kinase
(HSV-tk) gene transduction of rat C6 glioma cells followed by ganciclovir (GCV) …
(HSV-tk) gene transduction of rat C6 glioma cells followed by ganciclovir (GCV) …
Bystander Effect in Herpes Simplex Virus-Thymidine Kinase/Ganciclovir Cancer Gene Therapy: Role of Gap-junctional Intercellular Communication1
M Mesnil, H Yamasaki - Cancer research, 2000 - AACR
Antitumor suicide gene therapy is one of the emerging strategies against cancer. It consists
of the introduction into cancer cells of a gene capable of converting a nontoxic prodrug into a …
of the introduction into cancer cells of a gene capable of converting a nontoxic prodrug into a …
Glial connexins and pannexins in the healthy and diseased brain
C Giaume, CC Naus, JC Sáez… - Physiological …, 2021 - journals.physiology.org
Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …
main cell population in the brain, dynamically interact with neurons and thus impact their …
Deficiency of connexin43 gap junctions is an independent marker for breast tumors
Gap junctions are intercellular channels that are formed from members of a family of
proteins, the connexins (Cxs). Gap junctions play an important role in vital functions …
proteins, the connexins (Cxs). Gap junctions play an important role in vital functions …
Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential
KK Hirschi, CE Xu, T Tsukamoto, R Sager - Cell Growth and Differentiation …, 1996 - AACR
Normal human mammary epithelial cells express hcx43 and hCx26 proteins, which form
functional gap junction channels. Both Cx genes are transcriptionally down-regulated in …
functional gap junction channels. Both Cx genes are transcriptionally down-regulated in …
Tumor-suppressive effects of pannexin 1 in C6 glioma cells
Mammalian gap junction proteins, connexins, have long been implicated in tumor
suppression. Recently, a novel family of proteins named pannexins has been identified as …
suppression. Recently, a novel family of proteins named pannexins has been identified as …
Cancer connectors: connexins, gap junctions, and communication
Despite concerted clinical and research efforts, cancer is a leading cause of death
worldwide. Surgery, radiation, and chemotherapy have remained the most common …
worldwide. Surgery, radiation, and chemotherapy have remained the most common …