Signal transducer and activator of transcription (STAT) proteins are latent transcription
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …

In recent years, it has become clear that members of the signal transducer and activator of
transcription (STAT) family of genes play an important role in cancer. The STAT family …

Mature T-cell lymphomas, including peripheral T-cell lymphoma (PTCL) and extranodal
NK/T-cell lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas …

The association between cancer and autoimmune disease is unexplained, exemplified by T
cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic …

As a transcription factor, STAT3 protein transduces extracellular signals to the nucleus and
then activates transcription of target genes. STAT3 has been well validated as an attractive …

Signal Transducer and Activator of Transcription (STAT) 3 and 5 are important effectors of
cellular transformation, and aberrant STAT3 and STAT5 signaling have been demonstrated …

Large granular lymphocyte leukemia (LGLL) is a chronic proliferation of clonal cytotoxic
lymphocytes, usually presenting with cytopenias and yet lacking a specific therapy. The …

Dysregulation of T-cell–mediated immunity is responsible for acquired pure red cell aplasia
(PRCA). Although STAT3 mutations are frequently detected in patients with T-cell large …

Abstract Large Granular Lymphocyte Leukemia (LGLL) is a rare chronic lymphoproliferative
disorder characterized by the clonal expansion of Large Granular Lymphocytes (LGLs) …

LGL disorders are rare hematological neoplasias with remarkable phenotypic, genotypic
and clinical heterogeneity. Despite these constraints, many achievements have been …