B cells, plasma cells and antibody repertoires in the tumour microenvironment
Recent data show that B cells and plasma cells located in tumours or in tumour-draining
lymph nodes can have important roles in sha** antitumour immune responses. In tumour …
lymph nodes can have important roles in sha** antitumour immune responses. In tumour …
Beyond binding: antibody effector functions in infectious diseases
Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …
microorganisms or infected cells. Although preventing pathogen entry is one potential …
Challenges and opportunities for consistent classification of human B cell and plasma cell populations
I Sanz, C Wei, SA Jenks, KS Cashman… - Frontiers in …, 2019 - frontiersin.org
The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …
and pathogenic immune responses combined with technological advances have generated …
Role of human milk bioactives on infants' gut and immune health
Exclusive human milk feeding of the newborn is recommended during the first 6 months of
life to promote optimal health outcomes during early life and beyond. Human milk contains a …
life to promote optimal health outcomes during early life and beyond. Human milk contains a …
Origin and evolution of the adaptive immune system: genetic events and selective pressures
The adaptive immune system (AIS) in mammals, which is centred on lymphocytes bearing
antigen receptors that are generated by somatic recombination, arose approximately 500 …
antigen receptors that are generated by somatic recombination, arose approximately 500 …
Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA
Humoral immune responses at mucosal surfaces have historically focused on IgA. Growing
evidence highlights the complexity of IgA-inducing pathways and the functional impact of IgA …
evidence highlights the complexity of IgA-inducing pathways and the functional impact of IgA …
IgT, a primitive immunoglobulin class specialized in mucosal immunity
YA Zhang, I Salinas, J Li, D Parra, S Bjork, Z Xu… - Nature …, 2010 - nature.com
Teleost fish are the most primitive bony vertebrates that contain immunoglobulins. In contrast
to mammals and birds, these species are devoid of immunoglobulin A (IgA) or a functional …
to mammals and birds, these species are devoid of immunoglobulin A (IgA) or a functional …
B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen
Neutrophils use immunoglobulins to clear antigen, but their role in immunoglobulin
production is unknown. Here we identified neutrophils around the marginal zone (MZ) of the …
production is unknown. Here we identified neutrophils around the marginal zone (MZ) of the …
Human plasma protein N-glycosylation
Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …
V (D) J recombination, somatic hypermutation and class switch recombination of immunoglobulins: mechanism and regulation
X Chi, Y Li, X Qiu - Immunology, 2020 - Wiley Online Library
Immunoglobulins emerging from B lymphocytes and capable of recognizing almost all kinds
of antigens owing to the extreme diversity of their antigen‐binding portions, known as …
of antigens owing to the extreme diversity of their antigen‐binding portions, known as …