Abstract Aims Reactive astrocytes in Alzheimer's disease (AD) have traditionally been
demonstrated by increased glial fibrillary acidic protein (GFAP) immunoreactivity; however …

Background Neuroinflammation and immune responses occurring minutes to hours after
stroke are associated with brain injury after acute ischemic stroke (AIS). PPARγ coactivator …

Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is
still emerging. Here, we show a prominent role for cohesin in the expression of genes that …

Background In response to injury, neurons activate a program of organized axon self-
destruction initiated by the NAD+ hydrolase, SARM1. In healthy neurons SARM1 is …

Highlights•CTCF and cohesin are required for genome-wide organization of TADs.•TADs
and compartments are not hierarchical forms of chromatin organization.•Strong molecular …

Rationale: Mitochondrial dysfunction and oxidative stress occur in vascular dementia (VaD),
but the specific molecular mechanism regulating these events remains unclear. Peroxisome …

Background Traumatic brain injury (TBI) is a major cause of death and disability. T cells
were shown to infiltrate the brain during the first days after injury and to exacerbate tissue …

Signaling by insulin-like growth factor-1 (IGF-1) is essential for the development of the
central nervous system (CNS) and regulates neuronal survival and myelination in the adult …

The three-dimensional genome structure organized by CTCF is required for development.
Clinically identified mutations in CTCF have been linked to adverse developmental …

The infiltration of immune cells is observed in the epileptogenic zone; however, the
relationship between epilepsy and regulatory T cells (Tregs) remains only partially …