Cellular cullin RING ubiquitin ligases: druggable host dependency factors of cytomegaloviruses
T Becker, VTK Le-Trilling, M Trilling - International journal of molecular …, 2019 - mdpi.com
Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus that frequently causes
morbidity and mortality in individuals with insufficient immunity, such as transplant recipients …
morbidity and mortality in individuals with insufficient immunity, such as transplant recipients …
Hepatitis B virus HBx protein mediates the degradation of host restriction factors through the cullin 4 DDB1 E3 ubiquitin ligase complex
The hepatitis B virus (HBV) regulatory HBx protein is required for infection, and its binding to
cellular damaged DNA binding protein 1 (DDB1) is critical for this function. DDB1 is an …
cellular damaged DNA binding protein 1 (DDB1) is critical for this function. DDB1 is an …
GARP and EARP are required for efficient BoHV-1 replication as identified by a genome wide CRISPR knockout screen
The advances in gene editing bring unprecedented opportunities in high throughput
functional genomics to animal research. Here we describe a genome wide CRISPR …
functional genomics to animal research. Here we describe a genome wide CRISPR …
[HTML][HTML] 53BP1, a known chromatin-associated factor that promotes DNA damage repair, is differentially modulated during bovine herpesvirus 1 infection in vitro and …
H Zhao, X Fu, W Gu, X Ding, L Zhua - Veterinary Microbiology, 2025 - Elsevier
Abstract Bovine herpesvirus 1 (BoHV-1) productive infection induces the formation of DNA
double-strand breaks (DSBs), the most severe form of DNA lesions in cultured cells. 53BP1 …
double-strand breaks (DSBs), the most severe form of DNA lesions in cultured cells. 53BP1 …
Canonical and divergent N-terminal HBx isoform proteins unveiled: characteristics and roles during HBV replication
S Hernández, F Álvarez-Astudillo, D Garrido, C Prieto… - Biomedicines, 2021 - mdpi.com
Hepatitis B virus (HBV) X protein (HBx) is a viral regulatory and multifunctional protein. It is
well-known that the canonical HBx reading frame bears two phylogenetically conserved …
well-known that the canonical HBx reading frame bears two phylogenetically conserved …
Host cell neddylation facilitates alphaherpesvirus entry in a virus-specific and cell-dependent manner
BH Lee, G Tebaldi, SM Pritchard… - Microbiology Spectrum, 2022 - Am Soc Microbiol
ABSTRACT Herpes simplex virus 1 (HSV-1) commandeers the host cell proteasome at
several steps of its replication cycle, including entry. Here we demonstrate that HSV-2 …
several steps of its replication cycle, including entry. Here we demonstrate that HSV-2 …
VP8, the major tegument protein of Bovine Herpesvirus 1, interacts with cellular STAT1 and inhibits interferon beta signaling
S Afroz, R Brownlie, M Fodje… - Journal of …, 2016 - Am Soc Microbiol
The UL47 gene product, VP8, is the most abundant tegument protein of bovine herpesvirus
1 (BoHV-1). Previously, we demonstrated that a UL47-deleted BoHV-1 mutant (BoHV1 …
1 (BoHV-1). Previously, we demonstrated that a UL47-deleted BoHV-1 mutant (BoHV1 …
The major tegument protein of bovine Herpesvirus 1, VP8, interacts with DNA damage response proteins and induces apoptosis
ABSTRACT VP8, the UL47 gene product in bovine herpesvirus-1 (BoHV-1), is a major
tegument protein that is essential for virus replication in vivo. The major DNA damage …
tegument protein that is essential for virus replication in vivo. The major DNA damage …
[HTML][HTML] HMGA1 Plays a Role in Counteracting DNA Damage Induced by BoHV-1 Productive Infection
H Zhao, X Fu, X Ding, L Zhu - International Journal of Molecular Sciences, 2024 - mdpi.com
Bovine herpesvirus 1 (BoHV-1) productive infection induces the generation of DNA double-
strand breaks (DSBs), which may consequently lead to cell apoptosis. In response to DSBs …
strand breaks (DSBs), which may consequently lead to cell apoptosis. In response to DSBs …
The bovine herpesvirus-1 major tegument protein, VP8, interacts with host HSP60 concomitant with deregulation of mitochondrial function
S Afroz, R Brownlie, M Fodje - Virus research, 2019 - Elsevier
The UL 47 gene product, VP8, is a major tegument protein of BoHV-1. While VP8 is not
essential for virus replication in cell culture, a UL 47-deleted virus exhibits a smaller …
essential for virus replication in cell culture, a UL 47-deleted virus exhibits a smaller …