Mathematical modeling of cancer immunotherapy for personalized clinical translation
Encouraging advances are being made in cancer immunotherapy modeling, especially in
the key areas of develo** personalized treatment strategies based on individual patient …
the key areas of develo** personalized treatment strategies based on individual patient …
Application of adoptive cell therapy in hepatocellular carcinoma
D Wu, Y Li - Immunology, 2023 - Wiley Online Library
Hepatocellular carcinoma (HCC) remains a global health challenge. Novel treatment
modalities are urgently needed to extend the overall survival of patients. The liver plays an …
modalities are urgently needed to extend the overall survival of patients. The liver plays an …
Circulating tumor DNA adds specificity to PET after axicabtagene ciloleucel in large B-cell lymphoma
EA Dean, GJ Kimmel, MJ Frank, A Bukhari… - Blood …, 2023 - ashpublications.org
We examined the meaning of metabolically active lesions on 1-month restaging nuclear
imaging of patients with relapsed/refractory large B-cell lymphoma receiving axicabtagene …
imaging of patients with relapsed/refractory large B-cell lymphoma receiving axicabtagene …
Optimal dosage protocols for mathematical models of synergy of chemo-and immunotherapy
The release of tumor antigens during traditional cancer treatments such as radio-or
chemotherapy leads to a stimulation of the immune response which provides synergistic …
chemotherapy leads to a stimulation of the immune response which provides synergistic …
Spatially fractionated GRID radiation potentiates immune-mediated tumor control
Background Tumor-immune interactions shape a develo** tumor and its tumor immune
microenvironment (TIME) resulting in either well-infiltrated, immunologically inflamed tumor …
microenvironment (TIME) resulting in either well-infiltrated, immunologically inflamed tumor …
In silico cancer immunotherapy trials uncover the consequences of therapy-specific response patterns for clinical trial design and outcome
Late-stage cancer immunotherapy trials often lead to unusual survival curve shapes, like
delayed curve separation or a plateauing curve in the treatment arm. It is critical for trial …
delayed curve separation or a plateauing curve in the treatment arm. It is critical for trial …
Fractionated photoimmunotherapy stimulates an anti-tumour immune response: an integrated mathematical and in vitro study
MU Zahid, M Waguespack, RC Harman… - British journal of …, 2024 - nature.com
Background Advanced epithelial ovarian cancer (EOC) has high recurrence rates due to
disseminated initial disease presentation. Cytotoxic phototherapies, such as photodynamic …
disseminated initial disease presentation. Cytotoxic phototherapies, such as photodynamic …
The synergistic immunotherapeutic impact of engineered CAR-T cells with PD-1 blockade in lymphomas and solid tumors: a systematic review
Currently, therapies such as chimeric antigen receptor-T Cell (CAR-T) and immune
checkpoint inhibitors like programmed cell death protein-1 (PD-1) blockers are showing …
checkpoint inhibitors like programmed cell death protein-1 (PD-1) blockers are showing …
[HTML][HTML] Leveraging mathematical models to improve the statistical robustness of cancer immunotherapy trials
JHA Creemers, J Textor - Current Opinion in Systems Biology, 2025 - Elsevier
Cancer immunotherapy is an important application area for mathematical modeling. Current
modeling studies have a range of ambitious goals from dose optimization to creating “digital …
modeling studies have a range of ambitious goals from dose optimization to creating “digital …
[HTML][HTML] Predicting resistance and pseudoprogression: are minimalistic immunoediting mathematical models capable of forecasting checkpoint inhibitor treatment …
Background: The increased application of immune checkpoint inhibitors (ICIs) targeting PD-
1/PD-L1 in lung cancer treatment generates clinical need to reliably predict individual …
1/PD-L1 in lung cancer treatment generates clinical need to reliably predict individual …