Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

The regulated migration of cells is essential for development and tissue homeostasis, and
aberrant cell migration can lead to an impaired immune response and the progression of …

Human Blepharophimosis/ptosis/epicanthus inversus syndrome (BPES) type I is an
autosomal dominant disorder associated with premature ovarian failure (POF) caused by …

The pivotal point of vertebrate sex determination is the development of the gonad into a
testis or ovary, which governs phenotypic sex through the production of hormones. The …

The sex of an individual is determined by the fate of the gonad. While the expression of Sry
and Sox9 is sufficient to induce male development, we here show that female differentiation …

Azoospermia due to obstructive and non-obstructive mechanisms is a common
manifestation of male infertility accounting for 10-15% of such cases. Known genetic factors …

Spermatogenesis is a complex developmental process that ultimately generates mature
spermatozoa. This process involves a phase of proliferative expansion, meiosis, and …

Precise self-renewal of the germ cell lineage is fundamental to fertility and reproductive
success. The early precursors for the germ lineage, primordial germ cells (PGCs), survive …

The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …

Spermatogonial stem cells (SSCs) provide the foundation for spermatogenesis. In a manner
comparable to hematopoietic stem cell transplantation, SSCs colonize the niche of recipient …