Unconventional T cells in brain homeostasis, injury and neurodegeneration

M Lv, Z Zhang, Y Cui - Frontiers in Immunology, 2023 - frontiersin.org
The interaction between peripheral immune cells and the brain is an important component of
the neuroimmune axis. Unconventional T cells, which include natural killer T (NKT) cells …

Unlocking gut-liver-brain axis communication metabolites: energy metabolism, immunity and barriers

X Sun, M Shukla, W Wang, S Li - npj Biofilms and Microbiomes, 2024 - nature.com
The interaction between the gut-microbiota-derived metabolites and brain has long been
recognized in both health and disease. The liver, as the primary metabolic organ for …

Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease

JR Lopes, X Zhang, J Mayrink… - Proceedings of the …, 2023 - National Acad Sciences
Emerging evidence suggests that dysregulation of neuroinflammation, particularly that
orchestrated by microglia, plays a significant role in the pathogenesis of Alzheimer's disease …

Nanocarrier-mediated siRNA delivery: a new approach for the treatment of traumatic brain injury–related Alzheimer's disease

J **, H Zhang, Q Lu, L Tian, S Yao, F Lai… - Neural Regeneration …, 2025 - journals.lww.com
Traumatic brain injury and Alzheimer's disease share pathological similarities, including
neuronal loss, amyloid-β deposition, tau hyperphosphorylation, blood–brain barrier …

Astrocyte‐Derived Extracellular Vesicular miR‐143‐3p Dampens Autophagic Degradation of Endothelial Adhesion Molecules and Promotes Neutrophil …

X Wu, H Liu, Q Hu, J Wang, S Zhang, W Cui… - Advanced …, 2024 - Wiley Online Library
Pivotal roles of extracellular vesicles (EVs) in the pathogenesis of central nervous system
(CNS) disorders including acute brain injury are increasingly acknowledged. Through the …

Gamma-delta T cells suppress microbial metabolites that activate striatal neurons and induce repetitive/compulsive behavior in mice

LM Cox, BK Tatematsu, L Guo, DS LeServe… - Brain, Behavior, and …, 2024 - Elsevier
Intestinal γδ T cells play an important role in sha** the gut microbiota, which is critical not
only for maintaining intestinal homeostasis but also for controlling brain function and …

Elucidating the neuroimmunology of traumatic brain injury: methodological approaches to unravel intercellular communication and function

H Abou-El-Hassan, JD Bernstock, JI Chalif… - Frontiers in cellular …, 2023 - frontiersin.org
The neuroimmunology of traumatic brain injury (TBI) has recently gained recognition as a
crucial element in the secondary pathophysiological consequences that occur following …

Spatiotemporal orchestration of macrophage activation trajectories by Vγ4 T cells during skin wound healing

W Hu, X Zhang, Z Liu, J Yang, H Sheng, Z Liu, C Chen… - Iscience, 2024 - cell.com
Dysregulated macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2
phenotypes underlies impaired cutaneous wound healing. This study reveals Vγ4+ γδ T …

Self‐Healing COCu‐Tac Hydrogel Enhances iNSCs Transplantation for Spinal Cord Injury by Promoting Mitophagy via the FKBP52/AKT Pathway

Z Tian, HJ Hu, CC Chan, T Hu, C Cai, H Li… - Advanced …, 2025 - Wiley Online Library
In the realm of neural regeneration post‐spinal cord injury, hydrogel scaffolds carrying
induced neural stem cells (iNSCs) have demonstrated significant potential. However …

Key actors in neuropathophysiology: The role of γδ T cells

D Bulgur, RM Moura, JC Ribot - European Journal of …, 2024 - Wiley Online Library
The neuroimmune axis has been the focus of many studies, with special emphasis on the
interactions between the central nervous system and the different immune cell subsets. T …