In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …

Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …

Abstract Background PacBio high fidelity (HiFi) sequencing reads are both long (15–20 kb)
and highly accurate (> Q20). Because of these properties, they have revolutionised genome …

Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

Current knowledge of RNA virus biodiversity is both biased and fragmentary, reflecting a
focus on culturable or disease-causing agents. Here we profile the transcriptomes of over …

The origin and cellular complexity of eukaryotes represent a major enigma in biology.
Current data support scenarios in which an archaeal host cell and an alphaproteobacterial …

The endosymbiotic origin of mitochondria during eukaryogenesis has long been viewed as
an adaptive response to the oxygenation of Earth's surface environment, presuming a …

Algae and bacteria have coexisted ever since the early stages of evolution. This coevolution
has revolutionized life on earth in many aspects. Algae and bacteria together influence …

Over the recent years, much has been unraveled about the pro-inflammatory properties of
various mitochondrial molecules once they are leaving the mitochondrial compartment. On …

Mammalian mitochondrial DNA (mtDNA) encodes 13 proteins that are essential for the
function of the oxidative phosphorylation system, which is composed of four respiratory …