Modern simulation and modeling approaches to investigation of biomolecular structure and
function rely heavily on a variety of methods—water models—to approximate the influence …

SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of
nicotinamide adenine dinucleotide in its oxidized form (NAD+) during Wallerian …

Abstract The Adaptive Poisson–Boltzmann Solver (APBS) software was developed to solve
the equations of continuum electrostatics for large biomolecular assemblages that have …

Piezo1 and Piezo2 are mechanically activated ion channels that mediate touch perception,
proprioception and vascular development. Piezo proteins are distinct from other ion …

Computationally driven engineering of proteins aims to allow them to withstand an extended
range of conditions and to mediate modified or novel functions. Therefore, it is crucial to the …

Mitochondria have specialized ribosomes that have diverged from their bacterial and
cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large …

SF3b is a heptameric protein complex of the U2 small nuclear ribonucleoprotein (snRNP)
that is essential for pre-mRNA splicing. Mutations in the largest SF3b subunit …

Ferroptosis is a form of cell death characterized by phospholipid peroxidation, where
numerous studies have suggested that the induction of ferroptosis is a therapeutic strategy …

MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory
cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms …

Manipulation of monoterpene synthases to maximize flux towards targeted products from
GPP (geranyl diphosphate) is the main challenge for heterologous monoterpene …