Therapeutic potential of isoflavones with an emphasis on daidzein

MM Alshehri, J Sharifi-Rad… - Oxidative Medicine …, 2021 - Wiley Online Library
Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical
composition of daidzein is analogous to mammalian estrogens, and it could be useful with a …

[HTML][HTML] Botanicals in postmenopausal osteoporosis

W Słupski, P Jawień, B Nowak - Nutrients, 2021 - mdpi.com
Osteoporosis is a systemic bone disease characterized by reduced bone mass and the
deterioration of bone microarchitecture leading to bone fragility and an increased risk of …

Metabolic engineering of isoflavones: an updated overview

SI Sohn, S Pandian, YJ Oh, HJ Kang, WS Cho… - Frontiers in Plant …, 2021 - frontiersin.org
Isoflavones are ecophysiologically active secondary metabolites derived from the
phenylpropanoid pathway. They were mostly found in leguminous plants, especially in the …

[HTML][HTML] Scientific evidence supporting the beneficial effects of isoflavones on human health

S Gómez-Zorita, M González-Arceo… - Nutrients, 2020 - mdpi.com
Isoflavones are phenolic compounds with a chemical structure similar to that of estradiol.
They are present in several vegetables, mainly in legumes such as soy, white and red …

Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss

PA Jayusman, NS Nasruddin, B Baharin… - Frontiers in …, 2023 - frontiersin.org
Osteoporosis and periodontitis are two major chronic diseases of postmenopausal women.
The association between these two diseases are evident through systemic bone loss and …

Comprehensive evaluation of the role of soy and isoflavone supplementation in humans and animals over the past two decades

Y **ao, S Zhang, H Tong, S Shi - Phytotherapy Research, 2018 - Wiley Online Library
Soy and soy‐based foods are considered healthy, particularly in many Asia–Pacific
countries, where soy products have long been consumed. Soy and soy‐related products …

Soy isoflavones and bone health: focus on the RANKL/RANK/OPG pathway

SH Hooshiar, M Tobeiha… - BioMed research …, 2022 - Wiley Online Library
Bone remodels via resorption and formation, two phenomena that continuously occur in
bone turnover. The RANKL/RANK/OPG pathway is one of the several mechanisms that …

Effects of isoflavone interventions on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

K Sansai, M Na Takuathung, R Khatsri… - Osteoporosis …, 2020 - Springer
Isoflavones have a structure similar to 17β-estradiol, so they may be useful to
postmenopausal women in preventing bone loss related to estrogen deficiency. The present …

Reciprocal effect of environmental stimuli to regulate the adipogenesis and osteogenesis fate decision in bone marrow-derived mesenchymal stem cells (BM-MSCs)

X Xu, L Zhao, PD Terry, J Chen - Cells, 2023 - mdpi.com
Mesenchymal stem cells derived from bone marrow (BM-MSCs) can differentiate into
adipocytes and osteoblasts. Various external stimuli, including environmental contaminants …

Effects of phytoestrogens on reproductive organ health

S Swathi Krishna, BB Kuriakose… - Archives of Pharmacal …, 2022 - Springer
Phytoestrogens are non-steroidal, polyphenolic compounds that are derived from plants and
have biological properties similar to those of human estrogens. Their bioactivity, which is …