[HTML][HTML] Determinants of resident tissue macrophage identity and function
Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …
Microglia biology: one century of evolving concepts
Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …
a long time, they were primarily considered to be phagocytes responsible for removing …
Microglial regional heterogeneity and its role in the brain
YL Tan, Y Yuan, L Tian - Molecular psychiatry, 2020 - nature.com
Microglia have been recently shown to manifest a very interesting phenotypical
heterogeneity across different regions in the mammalian central nervous system (CNS) …
heterogeneity across different regions in the mammalian central nervous system (CNS) …
Uncovering sex differences of rodent microglia
There are inherent structural and functional differences in the central nervous systems
(CNS) of females and males. It has been gradually established that these sex-specific …
(CNS) of females and males. It has been gradually established that these sex-specific …
Early fate defines microglia and non-parenchymal brain macrophage development
Central nervous system (CNS) macrophages comprise microglia and border-associated
macrophages (BAMs) residing in the meninges, the choroid plexus, and the perivascular …
macrophages (BAMs) residing in the meninges, the choroid plexus, and the perivascular …
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic …
A Yim, C Smith, AM Brown - Immunological reviews, 2022 - Wiley Online Library
Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …
The emerging tale of microglia in psychiatric disorders
As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …
response and play an increasingly important role in maintaining homeostatic brain functions …
What do microglia really do in healthy adult brain?
Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood
without replacement by bone marrow-derived circulating cells. In inflammation, stroke …
without replacement by bone marrow-derived circulating cells. In inflammation, stroke …
Stress induced microglial activation contributes to depression
B Li, W Yang, T Ge, Y Wang, R Cui - Pharmacological research, 2022 - Elsevier
Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …
caused serious health and socio-economic burdens worldwide. A growing body of evidence …
Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination
Background Emerging RNA viruses that target the central nervous system (CNS) lead to
cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus …
cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus …