There is consensus that amelioration of the motor symptoms of Parkinson's disease is most
effective with l-DOPA (levodopa). However, this necessary therapeutic step is biased by an …

Parkinson's disease (PD) is predominantly idiopathic in origin, and a large body of evidence
indicates that gastrointestinal (GI) dysfunctions are a significant comorbid clinical feature; …

Non‐technical summary L‐Dopa is an effective medication for Parkinson's disease (PD), but
loses efficiency with time. This can be delayed by treatment with histamine antagonists. We …

Abstract l-DOPA (Levodopa) remains the gold standard for the treatment of motor symptoms
of Parkinson's disease (PD), despite indications that the drug may have detrimental effects in …

Tonic dopamine (DA) levels influence the activity of dopaminergic neurons and the
dynamics of fast dopaminergic transmission. Although carbon fiber microelectrodes and fast …

The aim of this work was to monitor the effects of extracellular α-synuclein on the firing
activity of midbrain neurons dissociated from substantia nigra TH-GFP mice embryos and …

Thyroid hormones (THs) and their derivatives require transmembrane transporters (TTs) to
mediate their translocation across the cell membrane. Among these TTs, the L-type amino …

DOPA-derived peptidomimetics are an attractive therapeutic tool for the treatment of
Parkinson's disease. Compounds with unusual O–C and N–C covalent bonds between …

Amino acid transporters are involved in functions reportedly linked to the sleep/wake cycle:
neurotransmitter synthesis and recycling, the regulation of synaptic strength, protein …

The L-type amino acid transporter 2 (LAT2) imports amino acids (AA) and also certain
thyroid hormones (TH), eg 3, 3′-T 2 and T 3, but not rT 3 and T 4. We utilized LAT2 …