Recent work has shown that ubiquitination leads to recognition of target proteins by diverse
ubiquitin receptors. One family of receptors delivers the ubiquitinated proteins to the …

Abstract Three deubiquitinating enzymes—Rpn11, Usp14, and Uch37—are associated with
the proteasome regulatory particle. These enzymes allow proteasomes to remove ubiquitin …

We develop coarse-grained models and effective energy functions for simulating
thermodynamic and structural properties of multiprotein complexes with relatively low …

Abstract The Ubiquitin Proteasome System (UPS) was discovered in two steps. Initially, APF-
1 (ATP-dependent proteolytic Factor 1) later identified as ubiquitin (Ub), a hitherto known …

The most frequent subtype of autosomal dominant inherited spinocerebellar ataxias is
caused by CAG repeat expansions of more than 55 units in the ataxin-3 gene. The clinical …

Ubiquitin (Ub) functions in many different biological pathways, where it typically interacts
with proteins that contain modular Ub recognition domains. One such recognition domain is …

Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component
but unknown pathophysiology. We used microarray technology to determine the expression …

The 26S proteasome is responsible for regulated proteolysis in eukaryotic cells. Its
substrates are diverse in structure, function, sequence length, and amino acid composition …

Recent studies, mainly in yeast, have identified various cofactors that associate with the 26S
proteasome and appear to influence its function. To identify these proteins in different cells …

The Josephin domain plays an important role in the cellular functions of ataxin-3, the protein
responsible for the neurodegenerative Machado–Joseph disease. We have determined the …