Escherichia coli DNA replication: the old model organism still holds many surprises

K Łazowski, R Woodgate… - FEMS Microbiology …, 2024 - academic.oup.com
Research on Escherichia coli DNA replication paved the groundwork for many breakthrough
discoveries with important implications for our understanding of human molecular biology …

Urinary Thioproline and Thioprolinyl Glycine as Specific Biomarkers of Formaldehyde Exposure in Humans

G Pan, CK Au, YH Ham, JZ Yu, Z Cai… - … Science & Technology, 2024 - ACS Publications
Assessment of personal formaldehyde (FA) exposure is most commonly carried out using
formate as a biomarker, as it is the major product from FA metabolism. However, formate …

Mass spectrometry-based assays for assessing replicative bypass and repair of DNA alkylation in cells

J Li, Z Hu, D Liu, P Wang - RSC advances, 2023 - pubs.rsc.org
Endogenous metabolism and environmental exposure can give rise to DNA alkylation,
which can elicit deleterious biological consequences. In the search for reliable and …

8-OxodGuo and Fapy•dG Mutagenicity in Escherichia coli Increases Significantly when They Are Part of a Tandem Lesion with 5-Formyl-2′-deoxyuridine

S Dasgupta, S Gao, H Yang… - Chemical research in …, 2024 - ACS Publications
Tandem lesions, which are defined by two or more contiguously damaged nucleotides, are a
hallmark of ionizing radiation. Recently, tandem lesions containing 5-formyl-2 …

[HTML][HTML] The biochemistry of the carcinogenic alcohol metabolite acetaldehyde

LA Thomas, RJ Hopkinson - DNA repair, 2024 - Elsevier
Acetaldehyde (AcH) is the first metabolite of ethanol and is proposed to be responsible for
the genotoxic effects of alcohol consumption. As an electrophilic aldehyde, AcH can form …