Single particle cryo-electron microscopy (cryo-EM) has matured into a robust method for the
determination of biological macromolecule structures in the past decade, complementing X …

G protein-coupled receptors (GPCRs) are the largest single family of cell surface receptors
encoded by the human genome and they play pivotal roles in co-ordinating cellular systems …

Methods are presented that detect three types of aberrations in single-particle cryo-EM data
sets: symmetrical and antisymmetrical optical aberrations and magnification anisotropy …

Electron cryomicroscopy can, in principle, determine the structures of most biological
molecules but is currently limited by access, specimen preparation difficulties, and cost. We …

Advances in microscopy instruments and image processing algorithms have led to an
increasing number of cryo-electron microscopy (cryo-EM) maps. However, building accurate …

This review summarizes the current state of methods and results achievable by cryo-electron
microscopy (cryo-EM) imaging for molecular, cell, and structural biologists who wish to …

Most information loss in cryogenic electron microscopy (cryo-EM) stems from particle
movement during imaging, which remains poorly understood. We show that this movement …

In the past few years, many exciting papers reported results based on crystal structure
determination by electron diffraction. The aim of this review is to provide general and …

Structure-based drug discovery (SBDD) is an indispensable approach for the design and
optimization of new therapeutic agents. Here, we highlight the rapid progress that has turned …

Cryo–electron microscopy (cryo-EM) continues its remarkable growth as a method for
visualizing biological objects, which has been driven by advances across the entire pipeline …