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Animal models of Long Covid: A hit-and-run disease
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused
more than 7 million deaths globally. Despite the presence of infection-and vaccine-induced …
more than 7 million deaths globally. Despite the presence of infection-and vaccine-induced …
Mx GTPases: dynamin-like antiviral machines of innate immunity
The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III
interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the …
interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the …
Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci
We report full-length draft de novo genome assemblies for 16 widely used inbred mouse
strains and find extensive strain-specific haplotype variation. We identify and characterize …
strains and find extensive strain-specific haplotype variation. We identify and characterize …
Genomes of the mouse collaborative cross
Abstract The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI)
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
Strategies for containing Ebola in west Africa
The ongoing Ebola outbreak poses an alarming risk to the countries of West Africa and
beyond. To assess the effectiveness of containment strategies, we developed a stochastic …
beyond. To assess the effectiveness of containment strategies, we developed a stochastic …
Immune genes are hotspots of shared positive selection across birds and mammals
Consistent patterns of positive selection in functionally similar genes can suggest a common
selective pressure across a group of species. We use alignments of orthologous protein …
selective pressure across a group of species. We use alignments of orthologous protein …
High-diversity mouse populations for complex traits
Contemporary mouse genetic reference populations are a powerful platform to discover
complex disease mechanisms. Advanced high-diversity mouse populations include the …
complex disease mechanisms. Advanced high-diversity mouse populations include the …
Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance
Existing mouse models of lethal Ebola virus infection do not reproduce hallmark symptoms
of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated …
of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated …
Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus
Y Chen, L Graf, T Chen, Q Liao, T Bai, PP Petric, W Zhu… - Science, 2021 - science.org
Zoonotic avian influenza A virus (IAV) infections are rare. Sustained transmission of these
IAVs between humans has not been observed, suggesting a role for host genes. We used …
IAVs between humans has not been observed, suggesting a role for host genes. We used …
Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies
A key aspect of TB pathogenesis that maintains Mycobacterium tuberculosis in the human
population is the ability to cause necrosis in pulmonary lesions. As co-evolution shaped M …
population is the ability to cause necrosis in pulmonary lesions. As co-evolution shaped M …