Role of neuroinflammation in neurodegeneration development

W Zhang, D **ao, Q Mao, H **a - Signal transduction and targeted …, 2023 - nature.com
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Translational molecular imaging and drug development in Parkinson's disease

A Haider, NH Elghazawy, A Dawoud… - Molecular …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects
elderly people and constitutes a major source of disability worldwide. Notably, the …

Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression

Q Lei, T Wu, J Wu, X Hu, Y Guan… - Molecular …, 2021 - spandidos-publications.com
Parkinson's disease (PD) is the second most common neurodegenerative disease amongst
the middle‑aged and elderly populations. Several studies have confirmed that the microbiota …

Role of peripheral immune cells-mediated inflammation on the process of neurodegenerative diseases

Q Yang, G Wang, F Zhang - Frontiers in Immunology, 2020 - frontiersin.org
Neurodegenerative diseases are characterized by progressive loss of selectively vulnerable
neuronal populations, which contrasts with selectively static loss of neurons due to toxic or …

[HTML][HTML] Progress of immunotherapy of anti-α-synuclein in Parkinson's disease

Z Wang, G Gao, C Duan, H Yang - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Many neurodegenerative diseases are characterized by progressive loss of neurons and
abnormal protein accumulation, including amyloid (A) β and tau in Alzheimer's disease and …

Parkinson disease: translating insights from molecular mechanisms to neuroprotection

SK Pirooznia, LS Rosenthal, VL Dawson… - Pharmacological …, 2021 - Elsevier
Parkinson disease (PD) used to be considered a nongenetic condition. However, the
identification of several autosomal dominant and recessive mutations linked to monogenic …

Emerging immunotherapies for Parkinson disease

SMA Zella, J Metzdorf, E Ciftci, F Ostendorf… - Neurology and …, 2019 - Springer
Symptomatic treatment options for Parkinson disease have steadily improved, and
individualized therapeutic approaches are becoming established for every stage of the …

Treating Parkinson's disease with antibodies: Previous studies and future directions

AM Castonguay, C Gravel… - Journal of Parkinson's …, 2021 - content.iospress.com
Parkinson's disease is a neurodegenerative disorder mainly characterized by the
degeneration of dopaminergic neurons in the substantia nigra. Degenerating neurons …

Targeting α-synuclein for PD therapeutics: a pursuit on all fronts

M Teil, ML Arotcarena, E Faggiani, F Laferriere… - Biomolecules, 2020 - mdpi.com
Parkinson's Disease (PD) is characterized both by the loss of dopaminergic neurons in the
substantia nigra and the presence of cytoplasmic inclusions called Lewy Bodies. These …

Active immunization therapies for Parkinson's disease and multiple system atrophy

A Schneeberger, L Tierney, M Mandler - Movement Disorders, 2016 - Wiley Online Library
Vaccination is increasingly being investigated as a potential treatment for synucleinopathies,
a group of neurodegenerative diseases including Parkinson's disease, multiple system …