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2023 ESC Guidelines for the management of cardiomyopathies: Developed by the task force on the management of cardiomyopathies of the European Society of …
• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …
off-label use of medication should be limited to situations where it is in the patient's interest …
Genome-wide association studies of cardiovascular disease
Genome-wide association studies (GWAS) aim to identify common genetic variants that are
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
Polygenic architecture of rare coding variation across 394,783 exomes
Recent genetic and genomic advancements have elucidated the complex etiology of
idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases …
idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases …
Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings
Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality, with
pathogenic variants found in about a third of cases. Large-scale genome-wide association …
pathogenic variants found in about a third of cases. Large-scale genome-wide association …
Current state and future of polygenic risk scores in cardiometabolic disease: a sco** review
A polygenic risk score (PRS) is derived from a genome-wide association study and
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …